Apoptosis of T lymphocytes in acute disseminated encephalomyelitis

被引：20

作者：

Bauer, J

Stadelmann, C

Bancher, C

Jellinger, K

Lassmann, H

机构：

[1] Univ Vienna, Inst Neurol, A-1090 Vienna, Austria

[2] Hosp Lainz, Dept Neurol, Vienna, Austria

[3] Lainz Hosp, Ludwig Boltzmann Inst Clin Neurobiol, A-1130 Vienna, Austria

来源：

ACTA NEUROPATHOLOGICA | 1999年 / 97卷 / 06期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1007/s004010051028

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Apoptosis has been shown to be an efficient mechanism involved in clearance of T lymphocytes from the brains of animals with acute experimental autoimmune encephalomyelitis (EAE), an animal model for human multiple sclerosis. in this report we describe a case of acute disseminated encephalomyelitis following general measles infection. In this disease, which closely mimics the pathology of acute EAE we found a high percentage (30%) of apoptotic T cells. This indicates that in both rodent and human brain clearance of T cell-mediated inflammation follows similar mechanisms.

引用

页码：543 / 546

页数：4

共 18 条

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