Cardioprotective Properties of Dimethyl Sulfoxide during Global Ischemia-Reperfusion of Isolated Rat Heart

被引：5

作者：

Dmitriev, Yu. V. ^{[1
]}

Minasian, S. M. ^{[1
,2
]}

Demchenko, E. A. ^{[1
]}

Galagudza, M. M. ^{[1
,2
]}

机构：

[1] VA Almazov Fed Heart Blood & Endocrinol Ctr, St Petersburg, Russia

[2] IP Pavlov St Petersburg State Med Univ, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 154卷 / 01期

关键词：

dimethyl sulfoxide; infarct size; cardioprotection; ischemia-reperfusion; INFARCTION;

D O I：

10.1007/s10517-012-1872-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Cardioprotective properties of dimethyl sulfoxide (DMSO) were studied in the isolated rat heart model. Intraperitoneal administration of DMSO to animals for 3 days before the experiment, but not addition of DMSO to the perfusate, reduced infarction size. Both intraperitoneal and intracoronary administration of DMSO reduced the severity of postischemic left-ventricular dysfunction.

引用

页码：47 / 50

页数：4

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