Analysis of a cone snail's killer cocktail - The milked venom of Conus geographus

被引：11

作者：

Bingham, Jon-Paul ^{[1
]}

Baker, Margaret R. ^{[1
]}

Chun, Joycelyn B. ^{[1
]}

机构：

[1] Univ Hawaii, Dept Mol Biosci & Bioengn, Coll Trop Agr & Human Resources, Honolulu, HI 96822 USA

来源：

TOXICON | 2012年 / 60卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Cone snail; Toxinology; Fatalities; Conus geographus; Envenomation; Conotoxins; Conopeptides; Mass spectrometry; Milked venom; PEPTIDES; RECEPTOR;

D O I：

10.1016/j.toxicon.2012.07.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

"Snails can kill" is a statement that receives much disbelief. Yet the venom from Conus geographus, as delivered by a disposable hypodermic-like needle, has indeed killed many unsuspecting human victims. Our understanding of their milked venom the essence of these fatalities, is in itself non-existent. Here, we present the molecular mass analysis of the milked venom of C geographus, providing the first insight into the composition of its deadly cocktail. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1166 / 1170

页数：5

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