Mapping sulcal pattern asymmetry and local cortical surface gray matter distribution in vivo:: Maturation in perisylvian cortices

被引:179
作者
Sowell, ER
Thompson, PM
Rex, D
Kornsand, D
Tessner, KD
Jernigan, TL
Toga, AW
机构
[1] Univ Calif Los Angeles, Lab Neuro Imaging, Los Angeles, CA 90095 USA
[2] Univ Calif San Diego, Dept Vet Affairs Med Ctr, Sch Med, San Diego, CA USA
[3] Univ Calif San Diego, Dept Psychiat, Sch Med, San Diego, CA 92103 USA
[4] Univ Calif San Diego, Dept Radiol, Sch Med, San Diego, CA 92103 USA
关键词
D O I
10.1093/cercor/12.1.17
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Previous in vivo morphometric studies of human brain maturation between childhood and young adulthood have revealed a spatial and temporal pattern of progressive brain changes that is consistent with the postmortem cytoarchitectonic and cognitive developmental literatures. In this study, we mapped age differences in structural asymmetries at the cortical surface in groups of normally developing children (7-11 years), adolescents (12-16 years) and young adults (23-30 years) using novel surface-based mesh modeling image analytic methods. We also assessed relationships between cortical surface sulcal asymmetry and the local density of the underlying cortical gray matter. Results from this study reveal that perisylvian sulcal asymmetries are much more prominent in the adults than in the children studied. The superior posterior extent of the Sylvian fissure in the right hemisphere is similar to7 mm more superior in the average adult than in the average child studied, whereas little difference is observed during this age range in the location of this anatomical structure in the left hemisphere. Age-related differences in Sylvian fissure asymmetry were significant (P = 0.0129, permutation test), showing increased asymmetry with increasing age, We also show age-related increases in local gray matter proportion bilaterally in the temporo-parietal cortices that are anatomically and temporally related to the sulcal asymmetries. Results from this cross-sectional study imply that asymmetries in the Sylvian fissure are dynamically changing into young adulthood and show that variability in brain tissue density is related to asymmetry in this region. These morphological differences may be related to changing cognitive abilities and are relevant in interpreting results from studies of abnormal brain development where perisylvian brain regions are implicated.
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页码:17 / 26
页数:10
相关论文
共 48 条
[1]   MORPHOMETRY OF THE SYLVIAN FISSURE AND THE CORPUS-CALLOSUM, WITH EMPHASIS ON SEX-DIFFERENCES [J].
ABOITIZ, F ;
SCHEIBEL, AB ;
ZAIDEL, E .
BRAIN, 1992, 115 :1521-1541
[2]  
BENES FM, 1994, ARCH GEN PSYCHIAT, V51, P477
[3]   Function of the left planum temporale in auditory and linguistic processing [J].
Binder, JR ;
Frost, JA ;
Hammeke, TA ;
Rao, SM ;
Cox, RW .
BRAIN, 1996, 119 :1239-1247
[4]  
Brodmann K, 1909, VERGLEICHENDE LOKALI
[5]   The human brain age 7-11 years: A volumetric analysis based on magnetic resonance images [J].
Caviness, VS ;
Kennedy, DN ;
Richelme, C ;
Rademacher, J ;
Filipek, PA .
CEREBRAL CORTEX, 1996, 6 (05) :726-736
[6]   Normal brain development and aging: Quantitative analysis at in vivo MR imaging in healthy volunteers [J].
Courchesne, E ;
Chisum, HJ ;
Townsend, J ;
Cowles, A ;
Covington, J ;
Egaas, B ;
Harwood, M ;
Hinds, S ;
Press, GA .
RADIOLOGY, 2000, 216 (03) :672-682
[7]  
EVANS AC, 1994, NATO ADV SCI INST SE, V264, P263
[8]   HUMAN-BRAIN - CYTOARCHITECTONIC LEFT-RIGHT ASYMMETRIES IN TEMPORAL SPEECH REGION [J].
GALABURDA, AM ;
SANIDES, F ;
GESCHWIND, N .
ARCHIVES OF NEUROLOGY, 1978, 35 (12) :812-817
[9]   CEREBRAL LATERALIZATION - BIOLOGICAL MECHANISMS, ASSOCIATIONS, AND PATHOLOGY .1. A HYPOTHESIS AND A PROGRAM FOR RESEARCH [J].
GESCHWIND, N ;
GALABURDA, AM .
ARCHIVES OF NEUROLOGY, 1985, 42 (05) :428-459
[10]   Brain development during childhood and adolescence: a longitudinal MRI study [J].
Giedd, JN ;
Blumenthal, J ;
Jeffries, NO ;
Castellanos, FX ;
Liu, H ;
Zijdenbos, A ;
Paus, T ;
Evans, AC ;
Rapoport, JL .
NATURE NEUROSCIENCE, 1999, 2 (10) :861-863