Immunogenicity of fowlpox virus expressing the avian influenza virus H5 gene (TROVAC AIV-H5) in cats

被引：23

作者：

Karaca, K

Swayne, DE

Grosenbaugh, D

Bublot, M

Robles, A

Spackman, E

Nordgren, R

机构：

[1] Merial Ltd, Athens, GA 30601 USA

[2] SE Poultry Res Lab, Athens, GA USA

[3] Merial SAS, Lyon, France

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2005年 / 12卷 / 11期

关键词：

D O I：

10.1128/CDLI.12.11.1340-1342.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccination of cats with fowlpox virus expressing the avian influenza (AI) virus H5 hemagglutinin gene (TROVAC AI) resulted in detectable hemagglutination inhibition (HI) antibody responses to the homologous A/Turkey/Ireland/1378/83 (H5N8) (A/tky/Ire/83) AI virus antigen. The HI antibody responses to heterologous A/Chicken/Indonesia/7/03 (H5N1) (A/ck/Indonesia/03) AI virus antigen were also detected in all vaccinated cats, but only after booster vaccinations. The vaccine described in this study and other poxvirus-vectored vaccines may be of value for the prophylaxis of AI virus-associated morbidity and mortality in mammals.

引用

页码：1340 / 1342

页数：3

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