Provisional QTL for circadian period of wheel running in laboratory mice: Quantitative genetics of period in RI mice

被引：17

作者：

Hofstetter, JR ^{[1
]}

Possidente, B

Mayeda, AR

机构：

[1] Richard L Roudebush Vet Adm Med Ctr, Dept Psychiat, Indianapolis, IN 46202 USA

[2] Skidmore Coll, Dept Biol, Saratoga Springs, NY 12866 USA

来源：

CHRONOBIOLOGY INTERNATIONAL | 1999年 / 16卷 / 03期

关键词：

circadian rhythm; free-running rhythm; genetic loci; locomotor activity; recombinant inbred;

D O I：

10.3109/07420529909116857

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wheel running was monitored in B x D recombinant inbred (RI) mice under dark-dark (DD) conditions, and the mean circadian period was calculated for each strain. There were significant differences for this trait among B x D recombinant inbred strains (p < .0001) and a narrow-sense heritability of 21%. Analysis of strain means and variances indicates that at least four segregating loci contribute to the genetic variance for the free-running circadian period in this population. Correlation of the strain means for the circadian period of wheel running for each RT strain against the distribution of markers at over 1500 loci along the mouse genome identified a number of provisional quantitative trait loci (QTL). There were provisional QTL for wheel running at p < .001 on chromosome 11 and at p < .01 on chromosomes 1, 6, 9, 17, and 19. Most were in agreement with a second analysis done under similar conditions.

引用

页码：269 / 279

页数：11

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