MutT-related error avoidance mechanism for DNA synthesis

被引：64

作者：

Sekiguchi, M ^{[1
]}

机构：

[1] KYUSHU UNIV,MED INST BIOREGULAT,FUKUOKA 81282,JAPAN

来源：

GENES TO CELLS | 1996年 / 1卷 / 02期

关键词：

D O I：

10.1046/j.1365-2443.1996.d01-232.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mutator mutants that show an increased frequency of spontaneous mutation have led to the elucidation of the multiple pathways of spontaneous mutagenesis. 8-Oxo-dGTP (8-oxo-7,8-dihydrodeoxyguanosine triphosphate) is formed in the nucleotide pool of a cell during normal cellular metabolism, and when it is incorporated into DNA causes mutation. MutT protein of Escherichia coli and related mammalian enzymes specifically degrade 8-oxo-dGTP to 8-oxo-dGMP, thereby preventing occurrence of transversion mutation. The gene encoding the human enzyme, designated MTH1 (for mutT homologue 1), maps to chromosome 7p22. These proteins may be responsible for genomic stability.

引用

页码：139 / 145

页数：7

共 37 条

[1] MOLECULAR-CLONING AND NUCLEOTIDE-SEQUENCE OF THE MUTT-MUTATOR OF ESCHERICHIA-COLI THAT CAUSES A-T TO C-G TRANSVERSION [J].