Immunopathology of the noninfectious posterior and intermediate uveitides

被引:84
作者
Boyd, SR
Young, S
Lightman, S
机构
[1] Moorfields Eye Hosp, Inst Ophthalmol, Dept Clin Ophthalmol, London EC1V 2PD, England
[2] Univ Toronto, St Michaels Hosp, Toronto, ON M5B 1W8, Canada
关键词
autoantibody; CD4+T cells; choroid; cytokines; immunopathology; uveitis;
D O I
10.1016/S0039-6257(01)00275-2
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
The posterior and intermediate uveitides share an underlying immune etiology; however, they can be clinically and immunopathologically distinguished, Although the initiating stimuli for posterior and intermediate uveities are not known, it is believed that an exogenous. agent (such as a bacterium or a virus) or an endogenous molecule may induce disease. In either case, T-helper lymphocytes in conjunction with human leukocyte antigens are likely to be involved. This review examines the epidemiology, histology, immunopathology, and theories of pathogenesis of several posterior and intermediate uveitides, including sympathetic ophthalmia, Vogt-Koyanagi-Harada syndrome, Behcet's disease, sarcoidosis, intermediate uveitis, white dot syndromes, and birdshot retinochoroidopathy. (Surv Ophdialmol 46:209-233, 2001. (C) 2001 by Elsevier Science Inc. All rights reserved.).
引用
收藏
页码:209 / 233
页数:25
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