Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose:: Involvement of sterol regulatory element-binding protein-1c

被引：41

作者：

Achouri, Y ^{[1
]}

Hegarty, BD ^{[1
]}

Allanic, D ^{[1
]}

Bécard, D ^{[1
]}

Hainault, I ^{[1
]}

Ferré, P ^{[1
]}

Foufelle, F ^{[1
]}

机构：

[1] Univ Paris 06, Ctr Rech Biomed Cordeliers, INSERM, U671, F-75270 Paris, France

来源：

BIOCHIMIE | 2005年 / 87卷 / 12期

基金：

英国医学研究理事会;

关键词：

hepatocyte; lipogenesis; diabetes;

D O I：

10.1016/j.biochi.2005.04.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a screen for sterol regulatory element-binding protein (SREBP)-1c target genes in the liver, we identified long chain fatty acyl-CoA synthetase 5 (ACS-5). Hepatic ACS-5 mRNA is poorly expressed during fasting and diabetes and strongly induced by carbohydrate refeeding and insulin treatment. In cultured hepatocytes, insulin and a high glucose concentration induce ACS-5 mRNA. Adenoviral overexpression of a nuclear form of SREBP-1c in liver of diabetic mice or in cultured hepatocytes mimics the effect of insulin to induce ACS-5. By contrast, a dominant negative form of SREBP-1c abolishes the effect of insulin on ACS-5 expression. The dietary and SREBP-1c-mediated insulin regulation of ACS-5 expression indicate that ACS-5 is involved in the anabolic fate of fatty acids. (C) 2005 Elsevier SAS. All rights reserved.

引用

页码：1149 / 1155

页数：7

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