Increase in apoptosis and concomitant reduction of ischemic lesion volume and evidence for synaptogenesis after transient focal cerebral ischemia in rat treated with staurosporine

被引：20

作者：

Chopp, M

Li, Y

Jiang, N

机构：

[1] Henry Ford Hosp, Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI 48202 USA

[2] Oakland Univ, Dept Phys, Rochester, MI 48309 USA

来源：

BRAIN RESEARCH | 1999年 / 828卷 / 1-2期

关键词：

apoptosis; synaptogenesis; tissue plasticity; rat; staurosporine; middle cerebral artery occlusion;

D O I：

10.1016/S0006-8993(99)01354-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We sought to determine whether induction of apoptosis alters an ischemic lesion. Rats were subjected to 2 h of middle cerebral artery occlusion (MCAo) and treated with staurosporine (n = 8) or vehicle (n = 4). Our data demonstrate that at 22 h after MCAo, staurosporine triggered a significant increase in apoptosis, a reduction of lesion volume and an increase of synaptophysin immunoreactivity, as compared to the control group. (C) 1999 Elsevier Science B.V. All rights reserved.

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收藏

页码：197 / 201

页数：5

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