Proteomic identification of lower apolipoprotein A-I in Alzheimer's disease

被引：73

作者：

Liu, HC

Hu, CJ

Chang, JG

Sung, SM

Lee, LS

Yuan, RY

Leu, SJ

机构：

[1] Taipei Med Univ, Grad Inst Cell & Mol Biol, Taipei, Taiwan

[2] Taipei Med Univ, Dept Neurol, Taipei, Taiwan

[3] Taipei City Hosp, Dept Psychiat, Taipei, Taiwan

[4] Taipei City Hosp, Dept Mol Med Lab, Taipei, Taiwan

[5] China Med Univ Hosp, Div Mol Med, Dept Med Res, Taipei, Taiwan

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2006年 / 21卷 / 03期

关键词：

Alzheimer's disease; proteomics; apolipoprotein A-I (ApoA-I); polymorphism;

D O I：

10.1159/000090676

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Many researches have been trying to find the potential biomarkers for Alzheimer's disease ( AD). We hereby used the proteomics method to search for protein expression differences in the serum between AD patients and controls. We enrolled 59 AD patients and 74 age- and sex-matched controls in this study. Ten AD patients and 10 controls were selected for proteomic analysis. Apolipoprotein A-I (ApoA-I) was found to have a lower expression in the AD group by a proteomics two-dimensional gel electrophoresis study. We further measured the serum ApoA-I level which was significantly lower in the AD patients (112.29 +/- 21.33 mg/dl) in comparison to the controls (144.53 +/- 19.91 mg/dl; p < 0.0002). Lower serum ApoA-I levels might be a potential biomarker for AD. Copyright (c) 2006 S. Karger AG, Basel.

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页码：155 / 161

页数：7

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