Spatial and temporal expression of p57KIP2 during murine lens development

被引：47

作者：

Lovicu, FJ ^{[1
]}

McAvoy, JW

机构：

[1] Univ Sydney, Dept Anat & Histol, Sydney, NSW 2006, Australia

[2] Univ Sydney, Inst Biomed Res F13, Sydney, NSW 2006, Australia

来源：

MECHANISMS OF DEVELOPMENT | 1999年 / 86卷 / 1-2期

关键词：

lens development; p57(KIP2); lens cell proliferation; fibre differentiation;

D O I：

10.1016/S0925-4773(99)00106-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The expression patterns of p57(KIP2), an important cyclin-dependent kinase inhibitor in the lens, is investigated. This study shows that the expression of p57 mRNA throughout lens morphogenesis and growth correlates with lens cell withdrawal from the cell cycle (shown by changing patterns of BrdU incorporation) and the onset of lens fibre differentiation (shown by beta-crystallin expression). p57 expression at the early stages of fibre differentiation make it a useful marker for the initiation of this process. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：165 / 169

页数：5

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