Role of ICAM-1 (CD54) in the development of murine cerebral malaria

被引:112
作者
Favre, N
Da Laperousaz, C
Ryffel, B
Weiss, NA
Imhof, BA
Rudin, W
Lucas, R
Piguet, PF [1 ]
机构
[1] Univ Geneva, Dept Pathol, CH-1211 Geneva, Switzerland
[2] Swiss Trop Inst, Dept Med Parasitol, CH-4002 Basel, Switzerland
[3] Univ Cape Town, Dept Immunol, ZA-7925 Cape Town, South Africa
[4] Univ Geneva, Dept Anesthesiol Pharmacol & Surg Intens Care, CH-1211 Geneva, Switzerland
关键词
malaria; ICAM-1; CD54; TNF; platelet; Plasmodium berghei ANKA;
D O I
10.1016/S1286-4579(99)80513-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In susceptible mouse strains, infection of mice with Plasmodium berghei ANKA (PbA) results in a lethal complication, cerebral malaria. Cerebral malaria is due to the immune response induced by the parasite, which result-a in an increased production of TNF, known to increase the expression of adhesion molecules on the endothelia. To investigate the role of the adhesion molecule ICAM-1 (CD54), we infected wild-type (+/+) and ICAM-1-deficient (-/-) mice with PbA. While +/+ mice died 6-8 days after infection, -/- mice survived > 15 days. Parasitaemia was similar in +/+ and -/- mice. Serum TNF concentration was increased by the infection and was significantly higher in infected +/+ than in -/- mice, However, TNF mRNA levels in spleen, lungs, and brain were elevated in both infected +/+ and -/- mice, For IFN-gamma, serum levels were similar in both groups. A breakdown of the blood-brain barrier was evident in infected +/+ mice only. Interestingly, thrombocytopenia was profound in infected +/+, but practically absent in -/- mice, Moreover, macrophage sequestration was evident in brain venules and lung capillaries of +/+ mice and was significantly less important in the alveolar capillaries of infected -/- mice. In contrast, neutrophil sequestration in the lung was similar in both +/+ and -/- mice. Sequestration of parasitized red blood cells was significantly greater in the alveolar capillaries from +/+ than -/- mice. These results indicate that while the immune response is similar in both +/+ and ICAM-1(-/-) mice, the absence of mortality in ICAM(-/-) mice correlates with a decrease of macrophage and parasitized RBC trapping and a less severe thrombocytopenia. (C) 1999 Editions sciencifiques et medicales Elsevier SAS.
引用
收藏
页码:961 / 968
页数:8
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