Tuberculosis in children and adults:: two distinct genetic diseases

被引：175

作者：

Alcaïs, A

Fieschi, C

Abel, L

Casanova, JL ^{[1
]}

机构：

[1] Univ Paris 05, Lab Human Genet Infect Dis, INSERM, U550,Necker Med Sch, F-75015 Paris, France

[2] St Louis Hosp, Adult Immunopathol Unit, F-75010 Paris, France

[3] Hop Necker Enfants Malad, Pediat Hematol Immunol Unit, F-75010 Paris, France

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 202卷 / 12期

关键词：

D O I：

10.1084/jem.20052302

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Disseminated disease in children and pulmonary disease in adults constitute two major epidemiological and clinical forms of tuberculosis. Paradoxically, only a small fraction of infected individuals develop clinical tuberculosis, typically one form of the disease or the other. Mendelian and complex genetic predispositions to tuberculosis were reported recently in children and adults, respectively. Here, we argue that tuberculosis and its clinical expression largely reflect the underlying human genetic background.

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页码：1617 / 1621

页数：5

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