Antiviral activities of extracts isolated from Terminalis chebula Retz., Sanguisorba officinalis L., Rubus coreanus Miq. and Rheum palmatum L. against hepatitis B virus

被引：73

作者：

Kim, TG ^{[1
]}

Kang, SY ^{[1
]}

Jung, KK ^{[1
]}

Kang, JH ^{[1
]}

Lee, E ^{[1
]}

Han, HM ^{[1
]}

Kim, SH ^{[1
]}

机构：

[1] Korea Food & Drug Adm, Natl Inst Toxicol Res, Dept Pharmacol, Seoul 122704, South Korea

来源：

PHYTOTHERAPY RESEARCH | 2001年 / 15卷 / 08期

关键词：

hepatitis B virus; HepG2; 2.2.15; cell; Korean plants;

D O I：

10.1002/ptr.832

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antiviral effects of aqueous extracts of Terminalis chebula Retz., Sanguisorba officinalis L., Rubus coreanus Miq. and Rheum palmatum L. were examined by a cell culture system using a hepatitis B virus (HBV) producing cell line, HepG2 2.2.15. The extracts were assayed for the inhibition of HBV multiplication by measurement of HBV DNA and surface antigen (HBsAg) levels in the extracellular medium of HepG2 2.2.15 cells after an 8-day treatment. All extracts decreased the levels of extracellular HBV virion DNA at concentrations ranging from 64 to 128 mug/mL and inhibited the secretion of HBsAg dose dependently. Of the four tested plants, Terminalis chebula exhibited the most prominent anti-HBV activities. Copyright (C) 2001 John Wiley & Sons, Ltd.

引用

页码：718 / 720

页数：3

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