Structural and functional properties of genes involved in human cancer

被引：76

作者：

Furney, SJ

Higgins, DG

Ouzounis, CA ^{[1
]}

López-Bigas, N

机构：

[1] EMBL Cambridge Outstn, European Bioinformat Inst, Computat Genom Grp, Cambridge CB10 1SD, England

[2] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dublin 4, Ireland

[3] Univ Pompeu Fabra, Ctr Genom Regulat, Genome Bioinformat Lab, E-08003 Barcelona, Spain

来源：

BMC GENOMICS | 2006年 / 7卷 / 1期

关键词：

D O I：

10.1186/1471-2164-7-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: One of the main goals of cancer genetics is to identify the causative elements at the molecular level leading to cancer. Results: We have conducted an analysis of a set of genes known to be involved in cancer in order to unveil their unique features that can assist towards the identification of new candidate cancer genes. Conclusion: We have detected key patterns in this group of genes in terms of the molecular function or the biological process in which they are involved as well as sequence properties. Based on these features we have developed an accurate Bayesian classification model with which human genes have been scored for their likelihood of involvement in cancer.

引用

页数：11

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