Alphavirus vectors for gene expression and vaccines

被引：91

作者：

Schlesinger, S

Dubensky, TW

机构：

[1] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[2] Chiron Technol, Gene Therapy & Vaccines, Emeryville, CA 94608 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1999年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0958-1669(99)00006-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Alphavirus expression vectors are finding novel uses in research. They are showing increasing promise as vaccines and are being developed for diagnostic assays of other viruses. Some highlights over the past couple of years include improvements in packaging of replicons, targeting of Sindbis virus replicons, stable cell lines that can be induced to produce replicons, and the isolation of noncytopathic variants of Sindbis virus replicons. Reports that alphavirus vectors can efficiently infect neurons in rat hippocampal slices should increase their use in neurobiological studies.

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收藏

页码：434 / 439

页数：6

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