Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors

被引：125

作者：

Ahn, JH

Kim, SJ

Park, WS

Cho, SY

Ha, JD

Kim, SS

Kang, SK

Jeong, DG

Jung, SK

Lee, SH

Kim, HM

Park, SK

Lee, KH

Lee, CW

Ryu, SE

Choi, JK

机构：

[1] Korea Res Inst Chem Technol, Bioorgan Sci Div, Taejon 305434, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Syst Proteom Res Ctr, Taejon 305333, South Korea

[3] Korea Res Inst Biosci & Biotechnol, Bioevaluat Ctr, Taejon 305333, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 11期

关键词：

rhodanine; cancer; metastasis; PRL-3; inhibitor;

D O I：

10.1016/j.bmcl.2006.02.060

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting IC50 value of 0.9 mu M in vitro and showed a reduced invasion in cell-based assay. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2996 / 2999

页数：4

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