Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation

被引：58

作者：

O'Shea, Derville ^{[1
]}

O'Riain, Ciaran ^{[1
]}

Gupta, Manu ^{[1
]}

Waters, Rachel ^{[2
]}

Yang, Youwen ^{[1
]}

Wrench, David ^{[1
]}

Gribben, John ^{[1
]}

Rosenwald, Andreas ^{[3
]}

Ott, German ^{[3
,4
]}

Rimsza, Lisa M. ^{[5
,6
]}

Holte, Harald ^{[7
]}

Cazier, Jean-Baptiste ^{[1
,8
]}

Johnson, Nathalie A. ^{[9
,10
]}

Campo, Elias ^{[11
,12
]}

Chan, Wing C. ^{[13
]}

Gascoyne, Randy D. ^{[1
]}

Young, Bryan D. ^{[1
]}

Staudt, Louis M. ^{[14
]}

Lister, T. Andrew ^{[1
]}

Fitzgibbon, Jude ^{[1
]}

机构：

[1] Barts & London Queen Marys Sch Med & Dent, Ctr Med Oncol, London EC1M 6BQ, England

[2] Univ Oxford, Ctr Stat Med, Oxford, England

[3] Univ Wurzburg, Inst Pathol, D-8700 Wurzburg, Germany

[4] Robert Bosch Krankenhaus, Dept Clin Pathol, Stuttgart, Germany

[5] Univ Arizona, Dept Pathol, Tucson, AZ USA

[6] Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA

[7] Univ Oslo, Rikshosp, Norwegian Radium Hosp, Canc Clin,Dept Oncol, N-0027 Oslo, Norway

[8] Canc Res UK, Bioinformat & Biostat, London, England

[9] British Columbia Canc Agcy, Dept Pathol, Vancouver, BC V5Z 4E6, Canada

[10] British Columbia Canc Agcy, Div Med Oncol, Vancouver, BC V5Z 4E6, Canada

[11] Univ Barcelona, IDIBAPS, Dept Pathol, Barcelona, Spain

[12] Univ Barcelona, IDIBAPS, Hosp Clin, Barcelona, Spain

[13] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA

[14] NCI, NIH, Metab Branch, Ctr Canc Res, Bethesda, MD 20892 USA

来源：

BLOOD | 2009年 / 113卷 / 10期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

GENE-EXPRESSION; COPY NUMBER; REVEALS; EVOLUTION; CELLS; ARRAY;

D O I：

10.1182/blood-2008-08-174953

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination. SNP array analysis was performed with the use of the Affymetrix 10K 2.0 Gene-chip array on DNA from 185 diagnostic FL patients to assess the prognostic relevance of aUPD. Genetic abnormalities were detected in 118 (65%) of 182 patients. Number of abnormalities was predictive of outcome; more than 3 abnormalities was associated with inferior overall survival (OS; P < .03). Sites of recurrent aUPD were detected on 6p (n = 25), 16p (n = 22), 12q (n = 17), 1p36 (n = 14), 10q (n = 8), and 6q (n = 8). On multivariate analysis aUPD on 1p36 correlated with shorter OS (P = .05). aUPD on 16p was predictive of transformation (P = .03) and correlated with poorer progression-free survival (P = .02). aUPD is frequent at diagnosis of FL and affects probability of disease transformation and clinical outcome. (Blood. 2009; 113: 2298-2301)

引用

页码：2298 / 2301

页数：4

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