Personalized medicine in metastatic non-small-cell lung cancer: promising targets and current clinical trials

被引：10

作者：

Black, A. ^{[1
]}

Morris, D. ^{[1
]}

机构：

[1] Univ Calgary, Dept Oncol, Calgary, AB, Canada

来源：

CURRENT ONCOLOGY | 2012年 / 19卷

关键词：

Lung cancer; clinical trials; novel targets; novel therapeutics; GROWTH-FACTOR RECEPTOR; HISTONE DEACETYLASE INHIBITOR; ANAPLASTIC LYMPHOMA KINASE; ANTITUMOR-ACTIVITY; PATIENTS PTS; 1ST-LINE TREATMENT; BRAF GENE; MUTATIONS; EGFR; ERLOTINIB;

D O I：

10.3747/co.19.1132

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer-related death globally, with most patients presenting with non-curable disease. Platinum-based doublet chemotherapy has been the cornerstone of treatment for patients with advanced-stage disease and has resulted in a modest increase in overall survival (on the order of an incremental 2 months increased survival per decade) and quality of life. Improved knowledge of the molecular signalling pathways found in NSCLC has led to the development of biomarkers with associated targeted therapeutics, thus changing the treatment paradigm for many NSCLC patients. In this review, we present a summary of many of the currently investigated NSCLC targets, discuss their current clinical trial status, and provide commentary as to the likelihood of their success making a positive impact for NSCLC patients.

引用

页码：S73 / S85

页数：13

共 52 条

[1]

Ras activation of the Raf kinase: Tyrosine kinase recruitment of the MAP kinase cascade [J].

Avruch, J ;

Khokhlatchev, A ;

Kyriakis, JM ;

Luo, ZJ ;

Tzivion, G ;

Vavvas, D ;

Zhang, XF .

RECENT PROGRESS IN HORMONE RESEARCH, VOL 56, 2001, 56 :127-155

[2]

Regulation, substrates and functions of src [J].

Brown, MT ;

Cooper, JA .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1996, 1287 (2-3) :121-149

[3]

Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: A systematic review and meta-analysis of individual patient data from 16 randomized controlled trials - NSCLC meta-analyses collaborative group [J].

Burdett, S. ;

Stephens, R. ;

Stewart, L. ;

Tierney, J. ;

Auperin, A. ;

Le Chevalier, T. ;

Le Pechoux, C. ;

Pignon, J. P. ;

Arriagada, R. ;

Higgins, J. ;

Johnson, D. ;

van Meerbeeck, J. ;

Parmar, M. ;

Souhami, R. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (28) :4617-4625

[4]

Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study [J].

Cappuzzo, Federico ;

Ciuleanu, Tudor ;

Stelmakh, Lilia ;

Cicenas, Saulius ;

Szczesna, Aleksandra ;

Juhasz, Erzsebet ;

Esteban, Emilio ;

Molinier, Olivier ;

Brugger, Wolfram ;

Melezinek, Ivan ;

Klingelschmitt, Gaelle ;

Klughammer, Barbara ;

Giaccone, Giuseppe .

LANCET ONCOLOGY, 2010, 11 (06) :521-529

[5]

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications [J].

Carnero, Amancio ;

Blanco-Aparicio, Carmen ;

Renner, Oliver ;

Link, Wolfgang ;

Leal, Juan F. M. .

CURRENT CANCER DRUG TARGETS, 2008, 8 (03) :187-198

[6]

Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells [J].

Catley, Laurence ;

Weisberg, Ellen ;

Kiziltepe, Tanyel ;

Tai, Yu-Tzu ;

Hideshima, Teru ;

Neri, Paola ;

Tassone, Pierfrancesco ;

Atadja, Peter ;

Chauhan, Dharminder ;

Munshi, Nikhil C. ;

Anderson, Kenneth C. .

BLOOD, 2006, 108 (10) :3441-3449

[7]

Mutations of the BRAF gene in human cancer [J].

Davies, H ;

Bignell, GR ;

Cox, C ;

Stephens, P ;

Edkins, S ;

Clegg, S ;

Teague, J ;

Woffendin, H ;

Garnett, MJ ;

Bottomley, W ;

Davis, N ;

Dicks, N ;

Ewing, R ;

Floyd, Y ;

Gray, K ;

Hall, S ;

Hawes, R ;

Hughes, J ;

Kosmidou, V ;

Menzies, A ;

Mould, C ;

Parker, A ;

Stevens, C ;

Watt, S ;

Hooper, S ;

Wilson, R ;

Jayatilake, H ;

Gusterson, BA ;

Cooper, C ;

Shipley, J ;

Hargrave, D ;

Pritchard-Jones, K ;

Maitland, N ;

Chenevix-Trench, G ;

Riggins, GJ ;

Bigner, DD ;

Palmieri, G ;

Cossu, A ;

Flanagan, A ;

Nicholson, A ;

Ho, JWC ;

Leung, SY ;

Yuen, ST ;

Weber, BL ;

Siegler, HF ;

Darrow, TL ;

Paterson, H ;

Marais, R ;

Marshall, CJ ;

Wooster, R .

NATURE, 2002, 417 (6892) :949-954

[8]

Somatic mutations affect key pathways in lung adenocarcinoma [J].

Ding, Li ;

Getz, Gad ;

Wheeler, David A. ;

Mardis, Elaine R. ;

McLellan, Michael D. ;

Cibulskis, Kristian ;

Sougnez, Carrie ;

Greulich, Heidi ;

Muzny, Donna M. ;

Morgan, Margaret B. ;

Fulton, Lucinda ;

Fulton, Robert S. ;

Zhang, Qunyuan ;

Wendl, Michael C. ;

Lawrence, Michael S. ;

Larson, David E. ;

Chen, Ken ;

Dooling, David J. ;

Sabo, Aniko ;

Hawes, Alicia C. ;

Shen, Hua ;

Jhangiani, Shalini N. ;

Lewis, Lora R. ;

Hall, Otis ;

Zhu, Yiming ;

Mathew, Tittu ;

Ren, Yanru ;

Yao, Jiqiang ;

Scherer, Steven E. ;

Clerc, Kerstin ;

Metcalf, Ginger A. ;

Ng, Brian ;

Milosavljevic, Aleksandar ;

Gonzalez-Garay, Manuel L. ;

Osborne, John R. ;

Meyer, Rick ;

Shi, Xiaoqi ;

Tang, Yuzhu ;

Koboldt, Daniel C. ;

Lin, Ling ;

Abbott, Rachel ;

Miner, Tracie L. ;

Pohl, Craig ;

Fewell, Ginger ;

Haipek, Carrie ;

Schmidt, Heather ;

Dunford-Shore, Brian H. ;

Kraja, Aldi ;

Crosby, Seth D. ;

Sawyer, Christopher S. .

NATURE, 2008, 455 (7216) :1069-1075

[9]

DIFFERENTIAL SENSITIVITY OF NORMAL AND TRANSFORMED HUMAN CELLS TO REOVIRUS INFECTION [J].

DUNCAN, MR ;

STANISH, SM ;

COX, DC .

JOURNAL OF VIROLOGY, 1978, 28 (02) :444-449

[10]

PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib [J].

Engelman, Jeffrey A. ;

Zejnullahu, Kreshnik ;

Gale, Christopher-Michael ;

Lifshits, Eugene ;

Gonzales, Andrea J. ;

Shimamura, Takeshi ;

Zhao, Feng ;

Vincent, Patrick W. ;

Naumov, George N. ;

Bradner, James E. ;

Althaus, Irene W. ;

Gandhi, Leena ;

Shapiro, Geoffrey I. ;

Nelson, James M. ;

Heymach, John V. ;

Meyerson, Matthew ;

Wong, Kwok-Kin ;

Janne, Pasi A. .

CANCER RESEARCH, 2007, 67 (24) :11924-11932

← 1 2 3 4 5 6 →