Photodynamic therapy-mediated DC immunotherapy is highly effective for the inhibition of established solid tumors

被引：49

作者：

Jung, Nam-Chul ^{[1
]}

Kim, Hee Jung ^{[1
]}

Kang, Mi-Sun ^{[2
]}

Lee, Jun-Ho ^{[1
]}

Song, Jie-Young ^{[3
]}

Seo, Han Geuk ^{[4
]}

Bae, Yong-Soo ^{[2
,5
]}

Lim, Dae-Seog ^{[1
]}

机构：

[1] CHA Univ, Dept Appl Biosci, Lab Immune Cell Based Therapy, Songnam 463836, Gyeonggi Do, South Korea

[2] CreaGene Inc, Res Inst DC Immunotherapy, Gyeonggi Do 462120, South Korea

[3] Korea Inst Radiol & Med Sci, Dept Radiat Canc Sci, Seoul 139706, South Korea

[4] Konkuk Univ, Dept Anim Biotechnol, Seoul 143701, South Korea

[5] Sungkyunkwan Univ, Dept Biol Sci, Gyeonggi Do 440746, South Korea

来源：

CANCER LETTERS | 2012年 / 324卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Dendritic cells; Photodynamic therapy; Immunotherapy; Heat shock proteins; HEAT-SHOCK PROTEINS; ADAPTIVE IMMUNE-RESPONSES; HEAT-SHOCK-PROTEIN-70 PEPTIDE COMPLEXES; ANTIGEN-PRESENTING CELLS; PULSED DENDRITIC CELLS; T-CELLS; INNATE; VACCINATION; RECEPTOR; CANCER;

D O I：

10.1016/j.canlet.2012.04.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dendritic cell (DC)-mediated immunotherapy has not been as effective as expected for most solid tumors. This study demonstrates immune responses against solid tumors mediated by DCs charged with photodynamic therapy (PDT)-induced tumor lysates, which contain the heat shock protein (HSP) 70. PDT tumor lysate-pulsed DC (PDT-DC) inhibited the growth of mammary EMT6 tumors to a greater extent than freeze/thawed tumor lysate-pulsed DC (FT-DC) or PDT tumor lysates. PDT-DC also showed significant anti-tumor effects against fully-established (i.e., late-stage) solid tumors. Taken together, these results suggest that PDT-DC vaccination is more effective than conventional DC therapy for the treatment of cancers. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：58 / 65

页数：8

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