Chromosomal inversion discovered in C3H/HeJ mice

被引：12

作者：

Akeson, EC ^{[1
]}

Donahue, LR ^{[1
]}

Beamer, WG ^{[1
]}

Shultz, KL ^{[1
]}

Ackert-Bicknell, C ^{[1
]}

Rosen, CJ ^{[1
]}

Corrigan, J ^{[1
]}

Davisson, MT ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

GENOMICS | 2006年 / 87卷 / 02期

关键词：

mouse; chromosomal inversion;

D O I：

10.1016/j.ygeno.2005.09.022

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mice of the inbred mouse strain C3H/HeJ have been shown to be homozygous for a chromosomal inversion on Chromosome (Chr) 6. The inversion encompasses about 20% of the chromosome from similar to 73 Mb to similar to 116 Mb. The importance of this finding is that linkage crosses using C3H/HeJ will show no recombination in this region of Chr 6. The inversion has no apparent effect on the phenotype of C3H/HeJ mice and its presence should not affect biological studies; however, use of C3H/HeJ mice for genetic analysis of Chr 6 should be avoided or the results interpreted with the inversion in mind. The inversion has been named In(6)1J (inversion Chr 6, Jackson 1). (C) 2005 Elsevier Inc. All rights reserved.

引用

页码：311 / 313

页数：3

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