Intentional overdose of Large Animal Immobilon

被引：11

作者：

Sterken, Joeri ^{[1
]}

Troubleyn, Joris ^{[2
]}

Gasthuys, Frank ^{[4
]}

Maes, Viviane ^{[3
]}

Diltoer, Mark ^{[2
]}

Verborgh, Christian ^{[1
]}

机构：

[1] Vrije Univ Brussel, Univ Hosp, Dept Emergency Med, B-1090 Brussels, Belgium

[2] Vrije Univ Brussel, Univ Hosp, Dept Intens Care, B-1090 Brussels, Belgium

[3] Vrije Univ Brussel, Univ Hosp, Dept Clin Chem, B-1090 Brussels, Belgium

[4] Univ Ghent, Fac Vet Med, Dept Surg & Anaesthesiol Domest Anim, Merelbeke, Belgium

来源：

EUROPEAN JOURNAL OF EMERGENCY MEDICINE | 2004年 / 11卷 / 05期

关键词：

Analgesics; opioid; etorphine; antagonists; diprenorphine; naloxone;

D O I：

10.1097/00063110-200410000-00013

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

We describe a case of voluntary self-injection with Large Animal Immobilon, a veterinary anaesthesia product containing etorphine, a very strong opioid, and acepromazine, a phenothiazine. This resulted in cardiorespiratory arrest and the need for sustained haemodynamic support after resuscitation. Large Animal Immobilon is used under specific conditions only, mainly in zoo and wildlife medicine. Primary toxicological analysis, although guided by the presumed toxin, could only detect a metabolite of acepromazine in the urine. Further analysis was able to show some traces of etorphine. A number of topics are treated, including the apparent potency of the etorphine and the selection of a suitable antidote, taking into account the different properties of the respective agents. (C) 2004 Lippincott Williams & Wilkins.

引用

页码：298 / 301

页数：4

共 29 条

[1]

[Anonymous], 1977, LANCET, V2, P178

[2]

BERKOWITZ BA, 1975, J PHARMACOL EXP THER, V195, P499

[3] PEDIATRIC ACEPROMAZINE POISONING - THE IMPORTANCE OF CHILD-RESISTANT PACKAGING FOR VETERINARY DRUGS [J].

BERNS, SD ;

WRIGHT, JL .

AMERICAN JOURNAL OF EMERGENCY MEDICINE, 1993, 11 (03) :247-248

[4]

BLANE GF, 1970, BRIT J PHARMACOL, V39, pP252

[5] ACTIONS OF ETORPHINE HYDROCHLORIDE (M99) - A POTENT MORPHINE LIKE AGENT [J].

BLANE, GF ;

BOURA, ALA ;

FITZGERALD, AE ;

LISTER, RE .

BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1967, 30 (01) :11-+

[6]

Bot G, 1998, J NEUROCHEM, V70, P358

[7]

Buss PE, 2001, J S AFR VET ASSOC, V72, P137

[8]

CLUTTON RE, 1985, VET HUM TOXICOL, V27, P391

[9]

DEROSSETT SE, 1984, J PHARMACOL EXP THER, V228, P669

[10]

DOBBS HE, 1968, J PHARMACOL EXP THER, V160, P407

← 1 2 3 →