Sexual development in a two-year-old boy induced by topical exposure to testosterone

被引：37

作者：

Yu, YM ^{[1
]}

Punyasavatsu, N ^{[1
]}

Elder, D ^{[1
]}

D'Ercole, AJ ^{[1
]}

机构：

[1] Univ N Carolina, Dept Pediat, Div Pediat Endocrinol, Chapel Hill, NC 27599 USA

来源：

PEDIATRICS | 1999年 / 104卷 / 02期

关键词：

testosterone; sexual development; childhood; topical exposure;

D O I：

10.1542/peds.104.2.e23

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

Virilization, including penile enlargement and growth of pubic hair and facial acne, developed in a 2-year-old boy over a period of months. This sexual development was induced by incidental and unintentional dermal exposure to a testosterone cream that was applied to his father's arm and back as a part of body building regimen. Except for penile size, the other signs of virilization diminished several months after the exposure was discontinued.

引用

页码：art. no. / e23

页数：2

共 12 条

[1]

TRANSDERMAL TESTOSTERONE THERAPY IN THE TREATMENT OF MALE HYPOGONADISM [J].

AHMED, SR ;

BOUCHER, AE ;

MANNI, A ;

SANTEN, RJ ;

BARTHOLOMEW, M ;

DEMERS, LM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 66 (03) :546-551

[2]

BENGALIM E, 1980, AM J DIS CHILD, V134, P296, DOI 10.1001/archpedi.1980.02130150050013

[3]

Gruelich WW, 1959, RADIOGRAPHIC ATLAS S

[4]

GRUMBACH MM, 1994, WILLIAMS TXB ENDOCRI, P1139

[5]

TESTOSTERONE TREATMENT FOR MICROPENIS DURING EARLY CHILDHOOD [J].

GUTHRIE, RD ;

SMITH, DW ;

GRAHAM, CB .

JOURNAL OF PEDIATRICS, 1973, 83 (02) :247-252

[6]

MICROPHALLUS - EVENTUAL PHALLIC SIZE IS DEPENDENT ON THE TIMING OF ANDROGEN ADMINISTRATION [J].

HUSMANN, DA ;

CAIN, MP .

JOURNAL OF UROLOGY, 1994, 152 (02) :734-739

[7]

Jacobs S C, 1975, Urology, V6, P708, DOI 10.1016/0090-4295(75)90801-8

[8]

RESPONSE OF MICROPENIS TO TOPICAL TESTOSTERONE AND GONADOTROPIN [J].

KLUGO, RC ;

CERNY, JC .

JOURNAL OF UROLOGY, 1978, 119 (05) :667-668

[9]

MICROPENIS - DOES EARLY TREATMENT WITH TESTOSTERONE DO MORE HARM THAN GOOD [J].

MCMAHON, DR ;

KRAMER, SA ;

HUSMANN, DA .

JOURNAL OF UROLOGY, 1995, 154 (02) :825-829

[10]

The effect of prepubertal, androgen exposure on adult penile length [J].

Sutherland, RS ;

Kogan, BA ;

Baskin, LS ;

Mevorach, RA ;

Conte, F ;

Kaplan, SL ;

Grumbach, MM .

JOURNAL OF UROLOGY, 1996, 156 (02) :783-787

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