Synthesis of azepane scaffolds on solid support for combinatorial chemistry

被引：26

作者：

Gauzy, L

Le Merrer, Y

Depezay, JC

Clerc, F

Mignani, S

机构：

[1] Univ Paris 05, Chim & Biochim Pharmacol & Toxicol Lab, CNRS, UMR 8601, F-75270 Paris 06, France

[2] Rhone Poulenc Rorer SA, Ctr Rech Vitry Alfortville, F-94403 Vitry Sur Sein, France

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 33期

关键词：

azepane; solid phase synthesis; combinatorial chemistry; Rink resin;

D O I：

10.1016/S0040-4039(99)01247-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiopure C-2-symmetric azepanes have been synthesized on solid support as scaffolds for the synthesis of peptidomimetics in combinatorial chemistry. The key step involves Pink resin as a formal equivalent of ammonia in the nucleophilic opening of L-iditol bis-epoxide. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：6005 / 6008

页数：4

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