Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells

被引:58
作者
Yeh, Chung-Hsin [1 ]
Shih, Hung-Che [2 ,3 ]
Hong, Hui-Mei [4 ]
Lee, Shiuan-Shinn [5 ]
Yang, Ming-Ling [6 ]
Chen, Chun-Jung [7 ,8 ]
Kuan, Yu-Hsiang [2 ,3 ]
机构
[1] Show Chwan Mem Hosp, Dept Neurol, Changhua, Taiwan
[2] Chung Shan Med Univ, Sch Med, Dept Pharmacol, Taichung 402, Taiwan
[3] Chung Shan Med Univ Hosp, Dept Pharm, Taichung, Taiwan
[4] Chung Shan Med Univ, Sch Biomed Sci, Taichung, Taiwan
[5] Chung Shan Med Univ, Sch Publ Hlth, Taichung, Taiwan
[6] Chung Shan Med Univ, Sch Med, Dept Anat, Taichung, Taiwan
[7] Taichung Vet Gen Hosp, Dept Educ & Res, Taichung, Taiwan
[8] Tunghai Univ, Ctr Gen Educ, Taichung 40704, Taiwan
关键词
Wogonin; BV2 microglial cells; STAT; Jak; antiinflammation; A-GLYCIDYL-METHACRYLATE; NECROSIS-FACTOR-ALPHA; ACUTE LUNG INJURY; SIGNAL-TRANSDUCTION; MACROPHAGES; ACTIVATION; STATS; PHOSPHORYLATION; SUPPRESSION; INHIBITION;
D O I
10.1177/0748233713485886
中图分类号
R1 [预防医学、卫生学];
学科分类号
100235 [预防医学];
摘要
Wogonin is a flavonoid compound which exhibits antioxidation, anti-inflammation, neuroprotection, and antitumorgenesis functions. However, the mechanism of how wogonin reduces proinflammatory cytokine generation in activated microglia is unclear. At present, we found wogonin inhibited lipopolysaccharide (LPS)-/interferon- (INF-)-induced generation of interleukin-6 (IL-6) and tumor necrosis factor- (TNF-). Wogonin exhibited parallel inhibition on LPS-/INF--induced expression of IL-6 and TNF- messenger RNA at the same concentration range. LPS-/INF--induced phosphorylation of signal transduction and transcription 1 and 3 (STAT1/3) were also inhibited by wogonin. Although wogonin expressed only weak inhibitory effect on LPS-/INF--induced phosphorylation of Janus kinase-2 (Jak-2) and tyrosine kinase (Tyk)-2, it significantly attenuated the phosphorylation of Jak-1 and Jak-3. These results indicated that the blockade of IL-6 and TNF- production by wogonin in LPS-/INF--stimulated BV2 microglial cells was attributed mainly to the interference in Jak-1/-3-STAT1/3 signaling pathway.
引用
收藏
页码:960 / 966
页数:7
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