The behavioral and neurochemical effects of phencyclidine in humans and animals: Some implications for modeling psychosis

被引：145

作者：

Steinpreis, RE

机构：

[1] Department of Psychology, University of Wisconsin at Milwaukee, 138 Garland Hall, Milwaukee, WI 53211

来源：

BEHAVIOURAL BRAIN RESEARCH | 1996年 / 74卷 / 1-2期

关键词：

phencyclidine; amphetamine; psychosis; schizophrenia model; behavioral effect; neurochemical effect;

D O I：

10.1016/0166-4328(95)00162-X

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Phencyclidine (PCP) produces a psychotic reaction in humans which closely resembles an acute episode of schizophrenia and has therefore been given an increasing amount of attention as a model for schizophrenia. The present article reviews the behavioral and neurochemical effects of PCP in both humans and animals. Where possible, comparisons are made between the effects of PCP and amphetamine. The merits of the dopamine versus NMDA/PCP receptor mediated expression of PCP-induced psychosis are discussed, as well as the importance of selecting behavioral models which are best suited to model the expression of psychosis, rather than the motor effects of psychotomimetics.

引用

页码：45 / 55

页数：11

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