Synthesis of Lipid-α-End-Functionalized Chains by RAFT Polymerization. Stabilization of Lipid/Polymer Particle Assemblies

被引：34

作者：

Bathfield, Mael ^{[1
,2
]}

Daviot, Delphine ^{[2
]}

D'Agosto, Franck ^{[1
]}

Spitz, Roger ^{[1
]}

Ladaviere, Catherine ^{[2
]}

Charreyre, Marie-Therese ^{[2
]}

Delair, Thierry ^{[2
]}

机构：

[1] Univ Lyon 1, Univ Lyon, CPE Lyon,CNRS UMR 5265,LCPP Team, Lab Chim Catalyse Polymeres & Procedes C2P2, F-69616 Villeurbanne, France

[2] Ecole Normale Super Lyon, Unite Mixte CNRS BioMerieux, F-69364 Lyon, France

来源：

MACROMOLECULES | 2008年 / 41卷 / 22期

关键词：

D O I：

10.1021/ma801567c

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A functional dithioester including a phospholipid moiety (Lipid-DT) has been synthesized in a high yield (71% after purification) from a precursor chain transfer agent (CTA) and fully characterized. The RAFT polymerization of an acrylamide derivative, N-acryloylmorpholine (NAM), mediated by this Lipid-DT exhibits a prolonged induction period in comparison with a nonfunctional dithioester. This phenomenon is discussed in terms of steric shielding induced by the bulky lipid moiety of the CTA. Moreover, the lipid moiety located at the a-end of the chains has a strong influence on the size exclusion chromatography analyses in THF using a standard-based calibration, with the suspicion of a retention phenomenon. The well-defined structure of the lipid-end-functionalized polymer chains has been evidenced by MALDI-TOF mass spectrometry. Finally, these chains have been successfully incorporated into lipid/polymer particle assemblies (LipoParticles) that resulted in an improved stabilization in aqueous medium at relatively high ionic strength (300 mM).

引用

页码：8346 / 8353

页数：8

共 81 条

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