Ischemic neurons recruit natural killer cells that accelerate brain infarction

被引：264

作者：

Gan, Yan ^{[1
,2
,3
]}

Liu, Qiang ^{[1
,2
,3
]}

Wu, Wei ^{[3
]}

Yin, Jun-Xiang ^{[3
]}

Bai, Xue-Feng ^{[4
]}

Shen, Rulong ^{[4
]}

Wang, Yongjun ^{[5
]}

Chen, Jieli ^{[6
]}

La Cava, Antonio ^{[7
]}

Poursine-Laurent, Jennifer ^{[8
,9
]}

Yokoyama, Wayne ^{[8
,9
]}

Shi, Fu-Dong ^{[1
,2
,3
]}

机构：

[1] Tianjin Med Univ, Gen Hosp, Tianjin & Minist Educ, Dept Neurol,Key Lab Neurorepair & Regenerat, Tianjin 300052, Peoples R China

[2] Tianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Tianjin 300052, Peoples R China

[3] St Josephs Hosp, Barrow Neurol Inst, Dept Neurol, Phoenix, AZ 85013 USA

[4] Ohio State Univ, Med Ctr, Dept Pathol, Columbus, OH 43210 USA

[5] Capital Med Univ, Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China

[6] Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[8] Washington Univ, Sch Med, Dept Med, Div Rheumatol, St Louis, MO 63110 USA

[9] Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2014年 / 111卷 / 07期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

innate immunity; middle cerebral artery occlusion; ischemic stroke; FRACTALKINE RECEPTOR CX(3)CR1; ROOT GANGLIA NEURONS; CEREBRAL-ISCHEMIA; MEDIATED LYSIS; T-CELLS; EXPRESSION; IDENTIFICATION; LYMPHOCYTES; MECHANISMS; STROKE;

D O I：

10.1073/pnas.1315943111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Brain ischemia and reperfusion activate the immune system. The abrupt development of brain ischemic lesions suggests that innate immune cells may shape the outcome of stroke. Natural killer (NK) cells are innate lymphocytes that can be swiftly mobilized during the earliest phases of immune responses, but their role during stroke remains unknown. Herein, we found that NK cells infiltrated the ischemic lesions of the human brain. In a mouse model of cerebral ischemia, ischemic neuron-derived fractalkine recruited NK cells, which subsequently determined the size of brain lesions in a T and B cell-independent manner. NK cell-mediated exacerbation of brain infarction occurred rapidly after ischemia via the disruption of NK cell tolerance, augmenting local inflammation and neuronal hyperactivity. Therefore, NK cells catalyzed neuronal death in the ischemic brain.

引用

页码：2704 / 2709

页数：6

共 33 条

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Direct NK cell-mediated lysis of syngenic dorsal root ganglia neurons in vitro [J].