Astrocytes couple synaptic activity to glucose utilization in the brain

被引:190
作者
Magistretti, PJ [1 ]
Pellerin, L [1 ]
机构
[1] Univ Lausanne, Fac Med, Inst Physiol, CH-1005 Lausanne, Switzerland
来源
NEWS IN PHYSIOLOGICAL SCIENCES | 1999年 / 14卷
关键词
D O I
10.1152/physiologyonline.1999.14.5.177
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Astrocytes have functional characteristics that make them particularly well suited to couple glutamate uptake from the synaptic cleft to Na+-K+-ATPase activation and glucose utilization. The changes in glucose metabolism associated with these processes may provide signals detected by positron emission tomography.
引用
收藏
页码:177 / 182
页数:6
相关论文
共 15 条
[1]   Synaptic activation of glutamate transporters in hippocampal astrocytes [J].
Bergles, DE ;
Jahr, CE .
NEURON, 1997, 19 (06) :1297-1308
[2]   Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain [J].
Bittar, PG ;
Charnay, Y ;
Pellerin, L ;
Bouras, C ;
Magistretti, PJ .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1996, 16 (06) :1079-1089
[3]   Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes - Expression of two different monocarboxylate transporters in astroglial cells and neurons [J].
Broer, S ;
Rahman, B ;
Pellegri, G ;
Pellerin, L ;
Martin, JL ;
Verleysdonk, S ;
Hamprecht, B ;
Magistretti, PJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (48) :30096-30102
[4]   The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: A microdialysis study [J].
Fray, AE ;
Forsyth, RJ ;
Boutelle, MG ;
Fillenz, M .
JOURNAL OF PHYSIOLOGY-LONDON, 1996, 496 (01) :49-57
[5]   Cellular bases of brain energy metabolism and their relevance to functional brain imaging: Evidence for a prominent role of astrocytes [J].
Magistretti, PJ ;
Pellerin, L .
CEREBRAL CORTEX, 1996, 6 (01) :50-61
[6]  
MAGISTRETTI PJ, 1997, PRIMER CEREBROVASCUL, P70
[7]   Expression of monocarboxylate transporter mRNAs in mouse brain: Support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain [J].
Pellerin, L ;
Pellegri, G ;
Martin, JL ;
Magistretti, PJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3990-3995
[8]  
Pellerin L, 1997, J NEUROCHEM, V69, P2132
[9]   GLUTAMATE UPTAKE INTO ASTROCYTES STIMULATES AEROBIC GLYCOLYSIS - A MECHANISM COUPLING NEURONAL-ACTIVITY TO GLUCOSE-UTILIZATION [J].
PELLERIN, L ;
MAGISTRETTI, PJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (22) :10625-10629
[10]   LACTATE RISE DETECTED BY H-1-NMR IN HUMAN VISUAL-CORTEX DURING PHYSIOLOGICAL STIMULATION [J].
PRICHARD, J ;
ROTHMAN, D ;
NOVOTNY, E ;
PETROFF, O ;
KUWABARA, T ;
AVISON, M ;
HOWSEMAN, A ;
HANSTOCK, C ;
SHULMAN, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (13) :5829-5831