Transfer RNA modification:: influence on translational frameshifting and metabolism

被引：99

作者：

Björk, GR ^{[1
]}

Durand, JMB ^{[1
]}

Hagervall, TG ^{[1
]}

Leipuviene, R ^{[1
]}

Lundgren, HK ^{[1
]}

Nilsson, K ^{[1
]}

Chen, P ^{[1
]}

Qian, Q ^{[1
]}

Urbonavicius, J ^{[1
]}

机构：

[1] Umea Univ, Dept Microbiol, S-90187 Umea, Sweden

来源：

FEBS LETTERS | 1999年 / 452卷 / 1-2期

关键词：

tRNA; modified nucleoside; frameshifting; central metabolism; virulence;

D O I：

10.1016/S0014-5793(99)00528-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transfer RNA modification improves the rate of aa-tRNA selection at the A-site and the fitness in the P-site and thereby prevents frameshifting according to a new model how frameshifting occurs [Qian et al. (1998) Mel. Cell 1, 471-482]. Evidence that the presence of various modified nucleosides in tRNA also influences central metabolism, thiamine metabolism, and bacterial virulence is reviewed, (C) 1999 Federation of European Biochemical Societies.

引用

页码：47 / 51

页数：5

共 41 条

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