Effect of intrastrain variation in the amount of capsular polysaccharide on genetic transformation of Streptococcus pneumoniae:: Implications for virulence studies of encapsulated strains

被引：47

作者：

Weiser, JN

Kapoor, M

机构：

[1] Univ Penn, Dept Microbiol, Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Pediat, Sch Med, Philadelphia, PA 19104 USA

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 07期

关键词：

D O I：

10.1128/IAI.67.7.3690-3692.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The degrees of competence of opaque and transparent colony variants of Streptococcus pneumoniae were compared. The transparent variants were transformed at 9- to 670-fold-higher rates than the opaque variants, independent of the DNA incorporated, due to decreased expression of capsular polysaccharide. Genetic transformation, therefore, tends to select for a less-encapsulated subpopulation.

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页码：3690 / 3692

页数：3

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