A quantitative immunohistochemical study on the time-dependent course of acute inflammatory cellular response to human brain injury

被引：63

作者：

Hausmann, R

Kaiser, A

Lang, C

Bohnert, M

Betz, P

机构：

[1] Univ Erlangen Nurnberg, Dept Legal Med, D-91054 Erlangen, Germany

[2] Klinikum Nurnberg, Inst Pathol, D-90419 Nurnberg, Germany

[3] Univ Wurzburg, Dept Legal Med, D-97078 Wurzburg, Germany

[4] Univ Freiburg, Dept Legal Med, D-79104 Freiburg, Germany

来源：

INTERNATIONAL JOURNAL OF LEGAL MEDICINE | 1999年 / 112卷 / 04期

关键词：

brain injury; cortical contusion; inflammatory reaction; immunohistochemistry; wound age;

D O I：

10.1007/s004140050241

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The time-dependent inflammatory cell reaction in human cortical contusions has been investigated during the first 30 weeks after blunt head injury. Immunohistochemical staining was carried out using CD 15 for granulocytes and LCA, CD 3 and UCHL-1 for mononuclear leucocytes. In order to provide reliable data for a forensic wound age estimation, the intensity of the cellular reaction was evaluated with a quantitative image analysis system. CD 15-labelled granulocytes were detectable earliest 10 min after brain injury, whereas significantly increased numbers of mononuclear leucocytes occurred in cortical contusions after a postinfliction interval of at least 1.1 days (LCA), 2 days (CD 3) or 3.7 days (UCHL-1), respectively.

引用

页码：227 / 232

页数：6

共 20 条

[1] THE ACUTE INFLAMMATORY RESPONSE TO LIPOPOLYSACCHARIDE IN CNS PARENCHYMA DIFFERS FROM THAT IN OTHER BODY-TISSUES [J].