Molecular modelling of CYP4A subfamily members based on sequence homology with CYP102

被引：22

作者：

Lewis, DFV ^{[1
]}

Lake, BG

机构：

[1] Univ Surrey, Sch Biol Sci, Mol Toxicol Grp, Guildford GU2 5XH, Surrey, England

[2] BIBRA Int, Carshalton SM5 4DS, Surrey, England

来源：

XENOBIOTICA | 1999年 / 29卷 / 08期

关键词：

D O I：

10.1080/004982599238227

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Homology modelling of various members of the CYP4A subfamily based on the CYP102 template structure is reported. 2. The binding interactions of specific substrates to the CYP4A forms from rat (CYP4A1), human (CYP4A11) and rabbit (CYP4A4) are shown to be consistent with experimental evidence regarding regioselectivity of metabolism. 3. The differences in substrate specificity between CYP4A1, CYP4A11 and CYP4A4 towards fatty acids and prostaglandins respectively are rationalized in terms of variations in active site amino residues.

引用

页码：763 / 781

页数：21

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