Inhibition of radiation-induced lipid peroxidation by curcumin

被引：86

作者：

Sreejayan, N

Rao, MNA

Priyadarsini, KI

Devasagayam, TPA

机构：

[1] COLL PHARMACEUT SCI,DEPT PHARMACEUT CHEM,MANIPAL 576119,KARNATAKA,INDIA

[2] BHABHA ATOM RES CTR,DIV CHEM,BOMBAY 400085,MAHARASHTRA,INDIA

[3] BHABHA ATOM RES CTR,RADIAT BIOL & BIOCHEM DIV,BOMBAY 400085,MAHARASHTRA,INDIA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1997年 / 151卷 / 01期

关键词：

curcumin; lipid peroxidation; antioxidant; tau-radiation;

D O I：

10.1016/S0378-5173(97)04900-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The ability of curcumin, a natural antioxidant from turmeric, to inhibit radiation-induced lipid peroxidation in rat liver microsomes was examined. Curcumin was incorporated into microsomes during ultracentrifugation. The antioxidant has significant time- and concentration-dependent inhibitory effect on lipid peroxidation induced by tau-radiation. Inhibition of lipid peroxidation was also observed in microsomes samples previously saturated with N2O. Curcumin also inhibited lipid peroxidation during the post-irradiation incubation. (C) 1997 Elsevier Science B.V.

引用

页码：127 / 130

页数：4

共 16 条

[1] PROTECTIVE EFFECTS OF CHLOROGENIC ACID, CURCUMIN AND BETA-CAROTENE AGAINST GAMMA-RADIATION-INDUCED IN-VIVO CHROMOSOMAL DAMAGE [J].