Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

被引：1382

作者：

Dinarello, Charles A. ^{[1
,2
]}

Simon, Anna ^{[2
]}

van der Meer, Jos W. M. ^{[2
]}

机构：

[1] Univ Colorado Denver, Dept Med, Aurora, CO 80045 USA

[2] Univ Med Ctr Nijmegen, Dept Med, NL-6500 HB Nijmegen, Netherlands

来源：

NATURE REVIEWS DRUG DISCOVERY | 2012年 / 11卷 / 08期

基金：

美国国家卫生研究院;

关键词：

JUVENILE IDIOPATHIC ARTHRITIS; FAMILIAL MEDITERRANEAN FEVER; COLD AUTOINFLAMMATORY SYNDROME; RECEPTOR ANTAGONIST ANAKINRA; MUCKLE-WELLS-SYNDROME; ONSET STILLS-DISEASE; HYPER-IGD SYNDROME; CYTOPHAGIC HISTIOCYTIC PANNICULITIS; MACROPHAGE ACTIVATION SYNDROME; QUALITY-OF-LIFE;

D O I：

10.1038/nrd3800

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Interleukin-1 (IL-1) is a highly active pro-inflammatory cytokine that lowers pain thresholds and damages tissues. Monotherapy blocking IL-1 activity in autoinflammatory syndromes results in a rapid and sustained reduction in disease severity, including reversal of inflammation-mediated loss of sight, hearing and organ function. This approach can therefore be effective in treating common conditions such as post-infarction heart failure, and trials targeting a broad spectrum of new indications are underway. So far, three IL-1-targeted agents have been approved: the IL-1 receptor antagonist anakinra, the soluble decoy receptor rilonacept and the neutralizing monoclonal anti-IL-1 beta antibody canakinumab. In addition, a monoclonal antibody directed against the IL-1 receptor and a neutralizing anti-IL-1 alpha antibody are in clinical trials.

引用

页码：633 / 652

页数：20

共 221 条

[1] Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction [J].

Abbate, Antonio ;

Salloum, Fadi N. ;

Vecile, Elena ;

Das, Anindita ;

Hoke, Nicholas N. ;

Straino, Stefania ;

Biondi-Zoccai, Giuseppe G. L. ;

Houser, Jon-Erik ;

Qureshi, Ian Z. ;

Ownby, Evan D. ;

Gustini, Edoardo ;

Biasucci, Luigi M. ;

Severino, Anna ;

Capogrossi, Maurizio C. ;

Vetrovec, George W. ;

Crea, Filippo ;

Baldi, Alfonso ;

Kukreja, Rakesh C. ;

Dobrina, Aldo .

CIRCULATION, 2008, 117 (20) :2670-2683

[2] Interleukin-1β modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouse [J].

Abbate, Antonio ;

Van Tassell, Benjamin W. ;

Seropian, Ignacio M. ;

Toldo, Stefano ;

Robati, Roshanak ;

Varma, Amit ;

Salloum, Fadi N. ;

Smithson, Lisa ;

Dinarello, Charles A. .

EUROPEAN JOURNAL OF HEART FAILURE, 2010, 12 (04) :319-322

[3] Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study) [J].

Abbate, Antonio ;

Kontos, Michael C. ;

Grizzard, John D. ;

Biondi-Zoccai, Giuseppe G. L. ;

Van Tassell, Benjamin W. ;

Robati, Roshanak ;

Roach, Lenore M. ;

Arena, Ross A. ;

Roberts, Charlotte S. ;

Varma, Amit ;

Gelwix, Christopher C. ;

Salloum, Fadi N. ;

Hastillo, Andrea ;

Dinarello, Charles A. ;

Vetrovec, George W. .

AMERICAN JOURNAL OF CARDIOLOGY, 2010, 105 (10) :1371-1377

[4]

ABRAHAM E, 1994, LYMPHOKINE CYTOK RES, V13, P343

[5] NALP3 forms an IL-lβ-Processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder [J].

Agostini, L ;

Martinon, F ;

Burns, K ;

McDermott, MF ;

Hawkins, PN ;

Tschopp, J .

IMMUNITY, 2004, 20 (03) :319-325

[6] Cryopyrin-Associated Periodic Syndromes: Otolaryngologic and Audiologic Manifestations [J].

Ahmadi, Neda ;

Brewer, Carmen C. ;

Zalewski, Christopher ;

King, Kelly A. ;

Butman, John A. ;

Plass, Nicole ;

Henderson, Cailin ;

Goldbach-Mansky, Raphaela ;

Kim, H. Jeffrey .

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2011, 145 (02) :295-302

[7] Anakinra efficacy in a Caucasian patient with renal AA amyloidosis secondary to cryopyrin-associated periodic syndrome [J].

Ait-Abdesselam, Tassadit ;

Lequerre, Thierry ;

Legallicier, Bruno ;

Francois, Arnaud ;

Loet, Xavier Le ;

Vittecoq, Olivier .

JOINT BONE SPINE, 2010, 77 (06) :616-617

[8] An Autoinflammatory Disease with Deficiency of the Interleukin-1-Receptor Antagonist [J].

Aksentijevich, Ivona ;

Masters, Seth L. ;

Ferguson, Polly J. ;

Dancey, Paul ;

Frenkel, Joost ;

van Royen-Kerkhoff, Annet ;

Laxer, Ron ;

Tedgard, Ulf ;

Cowen, Edward W. ;

Pham, Tuyet-Hang ;

Booty, Matthew ;

Estes, Jacob D. ;

Sandler, Netanya G. ;

Plass, Nicole ;

Stone, Deborah L. ;

Turner, Maria L. ;

Hill, Suvimol ;

Butman, John A. ;

Schneider, Rayfel ;

Babyn, Paul ;

El-Shanti, Hatem I. ;

Pope, Elena ;

Barron, Karyl ;

Bing, Xinyu ;

Laurence, Arian ;

Lee, Chyi-Chia R. ;

Chapelle, Dawn ;

Clarke, Gillian I. ;

Ohson, Kamal ;

Nicholson, Marc ;

Gadina, Massimo ;

Yang, Barbara ;

Korman, Benjamin D. ;

Gregersen, Peter K. ;

van Hagen, P. Martin ;

Hak, A. Elisabeth ;

Huizing, Marjan ;

Rahman, Proton ;

Douek, Daniel C. ;

Remmers, Elaine F. ;

Kastner, Daniel L. ;

Goldbach-Mansky, Raphaela .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (23) :2426-2437

[9] A retrospective review of autoinflammatory diseases in Saudi children at a rheumatology clinic [J].

Alenazi, Abdullatif ;

Al Sonbul, Abdullah ;

Al Jumaah, Suliman ;

Al Mehaidib, Ali ;

Al-Mayouf, Sulaiman M. .

ANNALS OF SAUDI MEDICINE, 2012, 32 (01) :43-48

[10] Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects [J].

Ali, Zahid ;

Laurijssens, Bart ;

Ostenfeld, Thor ;

McHugh, Simon ;

Stylianou, Anastasia ;

Scott-Stevens, Paul ;

Hosking, Louise ;

Dewit, Odile ;

Richardson, Jill C. ;

Chen, Chao .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 75 (01) :197-207

← 1 2 3 4 5 6 7 8 9 10 →