Ghrelin and cardiovascular health

被引：46

作者：

García, EA ^{[1
]}

Korbonits, M ^{[1
]}

机构：

[1] Barts & London Med Sch, William Harvey Res Inst, Dept Endocrinol, London EC1M 6BQ, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2006年 / 6卷 / 02期

关键词：

D O I：

10.1016/j.coph.2005.10.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ghrelin and its receptor are widely distributed in cardiovascular tissues, and there is no doubt that the effects of ghrelin in the cardiovascular system are mediated not only via its growth-hormone-releasing effect but also by direct effects on the heart. Indeed, new pharmacological approaches with animal and cell models using elegant study designs have described new functions of ghrelin, providing new potential therapeutic opportunities for ghrelin in cardiovascular medicine.

引用

页码：142 / 147

页数：6

共 34 条

[1] Myocardial ischemia differentially regulates LKB1 and an alternate 5′-AMP-activated protein kinase kinase [J].

Altarejos, JY ;

Taniguchi, M ;

Clanachan, AS ;

Lopaschuk, GD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (01) :183-190

[2] Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT [J].

Baldanzi, G ;

Filigheddu, N ;

Cutrupi, S ;

Catapano, F ;

Bonissoni, S ;

Fubini, A ;

Malan, D ;

Baj, G ;

Granata, R ;

Broglio, F ;

Papotti, M ;

Surico, N ;

Bussolino, F ;

Isgaard, J ;

Deghenghi, R ;

Sinigaglia, F ;

Prat, M ;

Muccioli, G ;

Ghigo, E ;

Graziani, A .

JOURNAL OF CELL BIOLOGY, 2002, 159 (06) :1029-1037

[3] Dual mechanisms regulating AMPK kinase action in the ischemic heart [J].

Baron, SJ ;

Li, J ;

Russell, RR ;

Neumann, D ;

Miller, EJ ;

Tuerk, R ;

Wallimann, T ;

Hurley, RL ;

Witters, LA ;

Young, LH .

CIRCULATION RESEARCH, 2005, 96 (03) :337-345

[4] Protective effects of ghrelin on ischemia/reperfusion injury in the isolated rat heart [J].

Chang, L ;

Ren, YS ;

Liu, XH ;

Li, WG ;

Yang, JH ;

Geng, B ;

Weintraub, NL ;

Tang, CS .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2004, 43 (02) :165-170

[5]

Chang L, 2004, ACTA PHARMACOL SIN, V25, P1131

[6] A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans [J].

Cummings, DE ;

Purnell, JQ ;

Frayo, RS ;

Schmidova, K ;

Wisse, BE ;

Weigle, DS .

DIABETES, 2001, 50 (08) :1714-1719

[7] Identification of the growth hormone-releasing peptide binding site in CD36: a photoaffinity cross-linking study [J].

Demers, A ;

McNicoll, N ;

Febbraio, M ;

Servant, M ;

Marleau, S ;

Silverstein, R ;

Ong, H .

BIOCHEMICAL JOURNAL, 2004, 382 :417-424

[8] Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells [J].

Dixit, VD ;

Schaffer, EM ;

Pyle, RS ;

Collins, GD ;

Sakthivel, SK ;

Palaniappan, R ;

Lillard, JW ;

Taub, DD .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (01) :57-66

[9] Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart [J].

Frascarelli, S ;

Ghelardoni, S ;

Ronca-Testoni, S ;

Zucchi, R .

BASIC RESEARCH IN CARDIOLOGY, 2003, 98 (06) :401-405

[10] New roles for the LKB1→AMPK pathway [J].

Hardie, DG .

CURRENT OPINION IN CELL BIOLOGY, 2005, 17 (02) :167-173

← 1 2 3 4 →