An integrated map with cosmid/PAC contigs of a 4-mb Down syndrome critical region

The major phenotypic features of Down syndrome have been correlated with partial trisomies of chromosome 21, allowing us to define the candidate gene region to a 4-Mb segment on the 21q22.2 band, We present here a high-resolution physical map with megabase-sized cosmid/PAC contigs, This ordered clone library has provided unique material for the integration of a variety of mappable objects, including exons, cDNAs, restriction sites, etc. Furthermore, our results have exemplified a strategy for the completion of the chromosome 21 map to sequencing. (C) 1996 Academic Press, Inc.