Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and -independent apoptotic signaling pathways

被引：131

作者：

Kawagoe, R ^{[1
]}

Kawagoe, H ^{[1
]}

Sano, K ^{[1
]}

机构：

[1] Kobe Univ, Sch Med, Dept Pediat, Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

LEUKEMIA RESEARCH | 2002年 / 26卷 / 05期

关键词：

valproic acid; apoptosis; leukemia; caspase-dependent and -independent pathways;

D O I：

10.1016/S0145-2126(01)00151-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the effects of valproic acid (VPA) on the growth and survival of human leukemia cell lines. VPA induced cell death in all of the nine cell lines tested in a dose dependent manner. VPA-treatment induced apoptotic changes in MV411 cells including DNA fragmentation, phosphatidylserine externalization, cytochrome c release from mitochondria, and activation of caspases-3, -8, and -9. A caspase inhibitor, zVAD-FMK, inhibited the DNA fragmentation induced by VPA but not cell death. These findings suggest that VPA exerts an anti-leukemic effect by both caspase-dependent and -independent apoptotic signaling pathways. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：495 / 502

页数：8

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