Growth-phase-dependent expression of virulence factors in an M1T1 clinical isolate of Streptococcus pyogenes

被引：51

作者：

Unnikrishnan, M ^{[1
]}

Cohen, J ^{[1
]}

Sriskandan, S ^{[1
]}

机构：

[1] Hammersmith Hosp, Imperial Coll Sch Med, Dept Infect Dis, London W12 0NN, England

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 10期

关键词：

D O I：

10.1128/IAI.67.10.5495-5499.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of growth phase on expression of virulence-associated factors was studied by Northern hybridization in an M1T1 clinical isolate of Streptococcus pyogenes. Expression of M protein, C5a peptidase, and capsule was maximal in the exponential phase of growth, while streptococcal pyrogenic exotoxins A and B and mitogenic factor were maximally expressed in later phases of growth.

引用

页码：5495 / 5499

页数：5

共 29 条

[1] Molecular analysis of the role of the group A streptococcal cysteine protease, hyaluronic acid capsule, and M protein in a murine model of human invasive soft-tissue infection [J].

Ashbaugh, CD ;

Warren, HB ;

Carey, VJ ;

Wessels, MR .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (03) :550-560

[2] RECOMBINATION-DEFICIENT MUTANTS OF SALMONELLA-TYPHIMURIUM ARE AVIRULENT AND SENSITIVE TO THE OXIDATIVE BURST OF MACROPHAGES [J].

BUCHMEIER, NA ;

LIPPS, CJ ;

SO, MYH ;

HEFFRON, F .

MOLECULAR MICROBIOLOGY, 1993, 7 (06) :933-936

[3] Temporal production of streptococcal erythrogenic toxin B (streptococcal cysteine proteinase) in response to nutrient depletion [J].

Chaussee, MS ;

Phillips, ER ;

Ferretti, JJ .

INFECTION AND IMMUNITY, 1997, 65 (05) :1956-1959

[4] High-frequency intracellular infection and erythrogenic toxin A expression undergo phase variation in M1 group A streptococci [J].

Cleary, PP ;

McLandsborough, L ;

Ikeda, L ;

Cue, D ;

Krawczak, J ;

Lam, H .

MOLECULAR MICROBIOLOGY, 1998, 28 (01) :157-167

[5] HYALURONIC-ACID SYNTHESIS OPERON (HAS) EXPRESSION IN GROUP-A STREPTOCOCCI [J].

CRATER, DL ;

VANDERIJN, I .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (31) :18452-18458

[6] Regulated transcription of Clostridium difficile toxin genes [J].

Dupuy, B ;

Sonenshein, AL .

MOLECULAR MICROBIOLOGY, 1998, 27 (01) :107-120

[7] Epidemiological and clinical aspects of invasive group A streptococcal infections and the streptococcal toxic shock syndrome [J].

Eriksson, BKG ;

Andersson, J ;

Holm, SE ;

Norgren, M .

CLINICAL INFECTIOUS DISEASES, 1998, 27 (06) :1428-1436

[8] MOLECULAR ANALYSIS OF PYROGENIC EXOTOXINS FROM STREPTOCOCCUS-PYOGENES ISOLATES ASSOCIATED WITH TOXIC SHOCK-LIKE SYNDROME [J].

HAUSER, AR ;

STEVENS, DL ;

KAPLAN, EL ;

SCHLIEVERT, PM .

JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (08) :1562-1567

[9] THE CHANGING EPIDEMIOLOGY OF INVASIVE GROUP-A STREPTOCOCCAL INFECTIONS AND THE EMERGENCE OF STREPTOCOCCAL TOXIC SHOCK-LIKE SYNDROME - A RETROSPECTIVE POPULATION-BASED STUDY [J].

HOGE, CW ;

SCHWARTZ, B ;

TALKINGTON, DF ;

BREIMAN, RF ;

MACNEILL, EM ;

ENGLENDER, SJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 269 (03) :384-389

[10] Mitogenic factor secreted by Streptococcus pyogenes is a heat-stable nuclease requiring His(122) for activity [J].

Iwasaki, M ;

Igarashi, H ;

Yutsudo, T .

MICROBIOLOGY-UK, 1997, 143 :2449-2455

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