Simultaneous determination of methadone, heroin, cocaine and their metabolites in urine by GC-MS

被引：12

作者：

Alvarez, I. ^{[1
]}

Palos, F. ^{[1
]}

Bermejo, A. M. ^{[1
]}

Fernandez, P. ^{[1
]}

Tabernero, M. J. ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Fac Med, Inst Legal Med, Forens Toxicol Serv, Santiago De Compostela 15782, Spain

来源：

ANALYTICAL LETTERS | 2006年 / 39卷 / 07期

关键词：

drugs of abuse; GC-MS; urine; liquid-liquid extraction; derivatization;

D O I：

10.1080/00032710600668699

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A gas chromatographic-mass spectrometric (GC-MS) method for the determination of methadone, heroin, cocaine, and their metabolites in urine using Selected Ion Monitoring (SIM) was developed. Following a liquid-liquid extraction with Toxitubes A trademark and using their deuterated analogs as internal standards, the analytes were derivatized with 99:1 (v/v) N,O-bis-trimethylsilyl-trifluoroacetamide/trimethylchlorosilane and injected by hand, in the splitless mode, at 240 degrees C and a purging time of 0.75 min. The mass selective detector was kept at 300 degrees C and molecules were ionized in the electron impact mode, using an energy of 70 eV. The detector response was linear for all drugs studied over the range 50-1000 ng/mL.

引用

页码：1393 / 1399

页数：7

共 14 条

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