Cutaneous T-cell lymphoma - Refinement in the application of controversial histologic criteria

The term cutaneous T-cell lymphoma was originally coined to encompass the spectrum of mycosis fungoides and Sezary syndrome. It has become increasingly evident that the histopathologic diagnosis of CTCL can be exceedingly challenging. A series of recent studies, however, have helped clarify the nature of the histologic findings in CTCL. Recently reported histologic data on mycosis fungoides, Sezary syndrome, and their variants is emphasized in this article, with special focus given to the findings in early lesions. A brief summary of lymphocyte immunophenotyping and the role of T-cell reception gene rearrangements in CTCL is included.