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TGF-beta as a T cell regulator in colitis and colon cancer

被引：80
作者：
Becker, C [1 ]
Fantini, MC [1 ]
Neurath, MF [1 ]
机构：
[1] Johannes Gutenberg Univ Mainz, Dept Med, Lab Clin Immunol 1, D-55131 Mainz, Germany
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2006年 / 17卷 / 1-2期
关键词：
TGF-beta; T cells; colitis; colon cancer;
D O I：
10.1016/j.cytogfr.2005.09.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TGF-beta is a pleiotropic cytokine with powerful immunosuppressive functions. Mice deficient for TGF-beta 1 show a dramatic phenotype with severe multiorgan inflammation and die shortly after birth. Recent investigations have highlighted the role of TGF-beta in suppression of T cell mediated autoimmunne inflammation and anti-tumor immunity. In addition to its direct anti-inflammatory effects on T cells, TGF-beta has been implicated as central regulator of regulatory T cells. TGF-beta not only mediates the suppression of effector T cells by Tregs, recent evidence also reveals a role for TGF-beta along with TCR stimulation in the peripheral induction of regulatory T cells from naive CD4+CD25- cells. (c) 2005 Elsevier Ltd. All rights reserved.
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页码：97 / 106
页数：10
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