MRP2 and 3 in health and disease

被引：93

作者：

Borst, P ^{[1
]}

Zelcer, N ^{[1
]}

van de Wetering, K ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Mol Biol, NL-1066 CX Amsterdam, Netherlands

来源：

CANCER LETTERS | 2006年 / 234卷 / 01期

关键词：

multidrug-resistance; transport; bile acids; morphine; allosteric stimulation;

D O I：

10.1016/j.canlet.2005.05.051

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MRPs are membrane proteins transporting organic anions at the expense of ATP hydrolysis. MRP2 is known to be a major transporter of organic anions from the liver into bile. We discuss recent results showing allosteric control of human but not rat MRP2. MRP3 has been considered a major player in bile salt metabolism, but our recent results with Mrp3 KO mice do not support this. Instead, we have found a role for MRP3 in the cellular export of drug-glucuronide conjugates. We discuss problems in extrapolating results obtained for murine MRPs. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：51 / 61

页数：11

共 51 条

[1] Sinusoidal efflux of taurocholate correlates with the hepatic expression level of Mrp3 [J].

Akita, H ;

Suzuki, H ;

Sugiyama, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 299 (05) :681-687

[2] Transport activity of human MRP3 expressed in Sf9 cells: Comparative studies with rat MRP3 [J].

Akita, H ;

Suzuki, H ;

Hirohashi, T ;

Takikawa, H ;

Sugiyama, Y .

PHARMACEUTICAL RESEARCH, 2002, 19 (01) :34-41

[3] Sinusoidal efflux of taurocholate is enhanced in Mrp2-deficient rat liver [J].

Akita, H ;

Suzuki, H ;

Sugiyama, Y .

PHARMACEUTICAL RESEARCH, 2001, 18 (08) :1119-1125

[4] Is there a toxicological advantage for non-hyperbolic kinetics in cytochrome P450 catalysis? Functional allostery from "distributrve catalysis" [J].

Atkins, WM ;

Lu, WYD ;

Cook, DL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (36) :33258-33266

[5] Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions [J].

Bakos, É ;

Evers, R ;

Sinkó, E ;

Váradi, A ;

Borst, P ;

Sarkadi, B .

MOLECULAR PHARMACOLOGY, 2000, 57 (04) :760-768

[6]

BELINSKY MG, 2005, MOL PHARM

[7] The role of multidrug, transporters in drug availability, metabolism and toxicity [J].

Bodó, A ;

Bakos, E ;

Szeri, F ;

Váradi, A ;

Sarkadi, B .

TOXICOLOGY LETTERS, 2003, 140 :133-143

[8] Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions [J].

Bodó, A ;

Bakos, E ;

Szeri, F ;

Váradi, A ;

Sarkadi, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (26) :23529-23537

[9]

BORST P, 2002, ANNU REV BIOCHEM, P37

[10]

BORST P, 2003, ABC PROTEINS BACTERI, P445

← 1 2 3 4 5 6 →