An IFNG polymorphism is associated with interferon-beta response in Spanish MS patients

被引：27

作者：

Martínez, A

de las Heras, V

Mas Fontao, A

Bartolomé, M

de la Concha, EG

Urcelay, E

Arroyo, R

机构：

[1] Hosp Clin San Carlos, Dept Clin Immunol, Madrid 28040, Spain

[2] Hosp Clin San Carlos, Multiple Sclerosis Unit, Madrid 28040, Spain

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2006年 / 173卷 / 1-2期

关键词：

multiple sclerosis; interferon microsatellite; pharmacogenetics;

D O I：

10.1016/j.jneuroim.2005.12.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interferon-beta is a biological treatment widely used in multiple sclerosis (MS). However, not every patient responds equally well to this therapy. In this study, our aim was to evaluate the influence of a dinucleotide microsatellite located in the first intron of the interferon-gamma gene on relapse eradication in a group of interferon-beta-treated patients. Our results show a very different allelic distribution when patients with relapses were compared with relapse-free patients. (c) 2005 Elsevier B.V. All rights reserved.

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收藏

页码：196 / 199

页数：4

相关论文

共 9 条

[1] New concepts in the immunopathogenesis of multiple sclerosis [J].

Hemmer, B ;

Archelos, JJ ;

Hartung, HP .

NATURE REVIEWS NEUROSCIENCE, 2002, 3 (04) :291-301

[2] IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response [J].

Leyva, L ;

Fernández, O ;

Fedetz, M ;

Blanco, E ;

Fernández, VE ;

Oliver, B ;

León, A ;

Pinto-Medel, MJ ;

Mayorga, C ;

Guerrero, M ;

Luque, G ;

Alcina, A ;

Matesanz, F .

JOURNAL OF NEUROIMMUNOLOGY, 2005, 163 (1-2) :165-171

[3] Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis [J].

McDonald, WI ;

Compston, A ;

Edan, G ;

Goodkin, D ;

Hartung, HP ;

Lublin, FD ;

McFarland, HF ;

Paty, DW ;

Polman, CH ;

Reingold, SC ;

Sandberg-Wollheim, M ;

Sibley, W ;

Thompson, AJ ;

van den Noort, S ;

Weinshenker, BY ;

Wolinsky, JS .

ANNALS OF NEUROLOGY, 2001, 50 (01) :121-127

[4]

PANITCH HS, 1987, LANCET, V1, P893

[5] A single nucleotide polymorphism in the first intron of the human IFN-γ gene:: Absolute correlation with a polymorphic CA microsatellite marker of high IFN-γ production [J].

Pravica, V ;

Perrey, C ;

Stevens, A ;

Lee, JH ;

Hutchinson, IV .

HUMAN IMMUNOLOGY, 2000, 61 (09) :863-866

[6] In vitro production of IFN-γ correlates with CA repeat polymorphism in the human IFN-γ gene [J].

Pravica, V ;

Asderakis, A ;

Perrey, C ;

Hajeer, A ;

Sinnott, PJ ;

Hutchinson, IV .

EUROPEAN JOURNAL OF IMMUNOGENETICS, 1999, 26 (01) :1-3

[7] A functional variant of IFNγ gene is associated with coeliac disease [J].

Rueda, B ;

Martínez, A ;

López-Nevot, MA ;

Mas-Fontao, A ;

Paco, L ;

Ortega, E ;

Fernández-Arquero, M ;

Urcelay, E ;

de la Concha, EG ;

Martín, J .

GENES AND IMMUNITY, 2004, 5 (06) :517-519

[8] The influence of strain and housing on two types of spike-wave discharges in rats [J].

Schridde, U ;

van Luijtelaar, G .

GENES BRAIN AND BEHAVIOR, 2004, 3 (01) :1-7

[9] Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis [J].

Sriram, U ;

Barcellos, LF ;

Villoslada, P ;

Rio, J ;

Baranzini, SE ;

Caillier, S ;

Stillman, A ;

Hauser, SL ;

Montalban, X ;

Oksenberg, JR .

GENES AND IMMUNITY, 2003, 4 (02) :147-152