Activation of programmed cell death (apoptosis) by adriamycin in human neoplastic cells

被引：7

作者：

Gruber, BM ^{[1
]}

Anuszewska, EL ^{[1
]}

Skierski, JS ^{[1
]}

机构：

[1] Drug Inst, Dept Vitamin Drugs, PL-00725 Warsaw, Poland

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2001年 / 484卷 / 1-2期

关键词：

adriamycin; apoptosis; flow cytometry;

D O I：

10.1016/S0027-5107(01)00256-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have studied the occurrence of the apoptosis phenomenon in the action of adriamycin (ADR) on human melanoma cells sensitive (ME18) and resistant (ME18/R) to ADR. The study has shown that the intensity of apoptotic morphological changes noted in melanoma cells depended on the duration of the ADR treatment. We have not observed any positive correlation between the induction of apoptosis and sensitivity to ADR. We have used a fluorescence microscope and flow cytometer to evaluate apoptotic events in cells treated with ADR. (C) 2001 Elsevier Science B.V All nights reserved.

引用

页码：87 / 93

页数：7

共 9 条

[1] Studies on adaptation to adriamycin in cells pretreated with hydrogen peroxide [J].

Anuszewska, EL ;

Gruber, BM ;

Koziorowska, JH .

BIOCHEMICAL PHARMACOLOGY, 1997, 54 (05) :597-603

[2]

Anuszewska Elzbieta L., 1994, Acta Biochimica Polonica, V41, P385

[3] Growth arrest and non-apoptotic cell death associated with the suppression of c-myc expression in MCF-7 breast tumor cells following acute exposure to doxorubicin [J].

Fornari, FA ;

Jarvis, WD ;

Grant, S ;

Orr, MS ;

Randolph, JK ;

White, FKH ;

Gewirtz, DA .

BIOCHEMICAL PHARMACOLOGY, 1996, 51 (07) :931-940

[4] A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics Adriamycin and daunorubicin [J].

Gewirtz, DA .

BIOCHEMICAL PHARMACOLOGY, 1999, 57 (07) :727-741

[5]

Han JW, 1997, CANCER RES, V57, P176

[6]

LING YH, 1993, CANCER RES, V53, P1845

[7] ADRIAMYCIN AND DAUNOMYCIN INDUCE PROGRAMMED CELL-DEATH (APOPTOSIS) IN TUMOR-CELLS [J].

SKLADANOWSKI, A ;

KONOPA, J .

BIOCHEMICAL PHARMACOLOGY, 1993, 46 (03) :375-382

[8] ABROGATION OF ADRIAMYCIN TOXICITY INVIVO BY CYCLOHEXIMIDE [J].

THAKKAR, NS ;

POTTEN, CS .

BIOCHEMICAL PHARMACOLOGY, 1992, 43 (08) :1683-1691

[9]

ZALESKIS G, 1994, MOL PHARMACOL, V46, P901

← 1 →