The detection of cardiotropic viruses in the myocardium of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy

OBJECTIVES We sought to investigate the role of cardiotropic viruses, including adenovirus, cytomegalo virus (CMV), enterovirus and parvovirus, in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). BACKGROUND Arrhythmogenic right ventricular dysplasia/cardiomyopathy, is characterized by, a gradual loss of myocytes, inflammatory, infiltrates and replacement by fatty and fibrous tissue. It has been speculated that ARVD/C is a sequela of viral myocarditis in some patients, and the role of the coxsackievirus B3 has been debated. METHODS Myocardial samples from 12 patients with ARVD/C were analyzed by, polymerase chain reaction for the presence of cardiotropic viruses. RESULTS Enteroviral sequences were detected in seven patients and adenovirus type 5 in another two patients. During the same period, 215 control samples were analyzed in which only, CMV (n = 2) and enterovirus (n = 1) were detected. This suggests a link between ARVD/C and the presence of viral genome (enterovirus or adenovirus) in the myocardium. CONCLUSIONS We report that cardiotropic viruses are more frequently identified in patients with ARVD/C than in control subjects. However, the role of these viruses in ARVD/C pathogenesis remains unknown. (C) 2002 by, the American College of Cardiology Foundation.