Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis

被引：201

作者：

Decramer, S

Wittke, S

Mischak, H

Zürbig, P

Walden, M

Bouissou, F

Bascands, JL

Schanstra, JP

机构：

[1] INSERM, U388, F-31432 Toulouse, France

[2] Univ Toulouse 3, Inst Louis Bugnard, IFR31, F-31432 Toulouse, France

[3] CHU Toulouse, Nephropediat Unit, Hop Enfants, F-31059 Toulouse 9, France

[4] Mosaiques Diagnost & Therapeut AG, D-30625 Hannover, Germany

来源：

NATURE MEDICINE | 2006年 / 12卷 / 04期

关键词：

D O I：

10.1038/nm1384

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We analyzed urinary polypeptides from individuals with neonatal ureteropelvic junction (UPJ) obstruction to predict which individuals with this condition will evolve toward obstruction that needs surgical correction. We identified polypeptides that enabled diagnosis of the severity of obstruction and validated these biomarkers in urine collected in a prospective blinded study. Using these noninvasive biomarkers, we were able to predict, several months in advance and with 94% precision, the clinical evolution of neonates with UPJ obstruction.

引用

页码：398 / 400

页数：3

共 13 条

[1] A mutation in the alpha 3 chain of type IX collagen causes autosomal dominant multiple epiphyseal dysplasia with mild myopathy [J].