New nitrogenous and aromatic derivatives from Aglaia argentea and A-forbesii

被引：76

作者：

Dumontet, V

Thoison, O

Omobuwajo, OR

Martin, MT

Perromat, G

Chiaroni, A

Riche, C

Pais, M

Sevenet, T

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

[2] UNIV MALAYA,DEPT CHEM,KUALA LUMPUR 59100,MALAYSIA

来源：

TETRAHEDRON | 1996年 / 52卷 / 20期

关键词：

D O I：

10.1016/0040-4020(96)00322-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Seeds and leaves of Aglaia orgentea and bark of A. forbesii were extracted, The known cyclopentatetrahydrobenzofuran derivative rocaglaol (1) and the aminopyrrolidine odorine (5), were isolated together with nine new compounds : didesmethylrocaglamide (6), aglains A (7), 8 (8) and C (9), aglaforbesins A (10) and B (11), ethylrocaglaol (12) and forbaglins A (13) and B (14). Compounds 7-11 and 13,14 possess a new cyclopentatetrahydrobenzopyran and benzoxepine skeleton, respectively, linked to an odorine type moiety. All the structures were elucidated notably by 2D NMR spectroscopy. In addition, the structure of forbaglin A was established by X-Ray crystallographic analysis. Didesmethylrocaglamide revealed strong cytotoxic activity against KB cells (IC50 0.006 mu g/ml). Copyright (C) 1996 Elsevier Science Ltd

引用

页码：6931 / 6942

页数：12

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