Gene therapy for osteoinduction

被引：54

作者：

Scaduto, AA ^{[1
]}

Lieberman, JR ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Med Ctr, Sch Med, Dept Orthopaed Surg, Los Angeles, CA 90095 USA

来源：

ORTHOPEDIC CLINICS OF NORTH AMERICA | 1999年 / 30卷 / 04期

关键词：

D O I：

10.1016/S0030-5898(05)70115-2

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

One application of gene therapy that holds great promise is the stimulation of bone formation. Gene therapy offers several potential advantages over other methods of osteoinduction and current research suggests that it may be a feasible treatment option for the orthopedic surgeon in the near future. This article reviews the basic concepts and strategies of gene therapy and evaluates the current research using gene therapy to induce bone formation and enhance healing.

引用

页码：625 / +

页数：10

共 54 条

[1] LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors [J].

Allay, JA ;

Dennis, JE ;

Haynesworth, SE ;

Majumdar, MK ;

Clapp, DW ;

Shultz, LD ;

Caplan, AI ;

Gerson, SL .

HUMAN GENE THERAPY, 1997, 8 (12) :1417-1427

[2]

Anderson WF, 1998, NATURE, V392, P25

[3] FIBROBLAST GROWTH-FACTOR STIMULATES BONE-FORMATION - BONE INDUCTION STUDIED IN RATS [J].

ASPENBERG, P ;

LOHMANDER, LS .

ACTA ORTHOPAEDICA SCANDINAVICA, 1989, 60 (04) :473-476

[4]

BALTZER A, 1999, T ORTHOPAEDIC RES SO

[5] ILIAC CREST BONE-GRAFT HARVEST DONOR SITE MORBIDITY - A STATISTICAL EVALUATION [J].

BANWART, JC ;

ASHER, MA ;

HASSANEIN, RS .

SPINE, 1995, 20 (09) :1055-1060

[6]

BECK LS, 1991, J BONE MINER RES, V6, P961

[7] AN EFFICIENT AND FLEXIBLE SYSTEM FOR CONSTRUCTION OF ADENOVIRUS VECTORS WITH INSERTIONS OR DELETIONS IN EARLY REGION-1 AND REGION-3 [J].

BETT, AJ ;

HADDARA, W ;

PREVEC, L ;

GRAHAM, FL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (19) :8802-8806

[8] 1998 Volvo Award winner in basic science studies - Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1) [J].

Boden, SD ;

Titus, L ;

Hair, G ;

Liu, YS ;

Viggeswarapu, M ;

Nanes, MS ;

Baranowski, C .

SPINE, 1998, 23 (23) :2486-2492

[9] LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone formation [J].

Boden, SD ;

Liu, YS ;

Hair, GA ;

Helms, JA ;

Hu, D ;

Racine, M ;

Nanes, MS ;

Titus, L .

ENDOCRINOLOGY, 1998, 139 (12) :5125-5134

[10] Use of bone morphogenetic protein-2 in the rabbit ulnar nonunion model [J].

Bostrom, M ;

Lane, JM ;

Tomin, E ;

Browne, M ;

Berberian, W ;

Turek, T ;

Smith, J ;

Wozney, J ;

Schildhauer, T .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 1996, (327) :272-282

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